Outcomes of alternative therapy in HLA-B* 13:01 positive leprosy patients without dapsone versus standard MDT in negative patients: A comparative effectiveness study.

However, in the aBI ≥ 4 stratum, the MDT group generally exhibited a higher BI reduction trend than the alternative group, reaching statistical significance particularly in the 4th year, with the decrease rates of 88.64% (MDT) versus 73.22% (alternative) ( P = 0.04), albeit marginally significant ( Fig 3c ).

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Overall, the MDT group demonstrated a more pronounced BI decline trend compared to the alternative regimen ( Fig 3a ), although this difference did not reach statistical significance.

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