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A Single Bout of Aerobic Exercise Increases Neuronal Extracellular Vesicle-Derived Insulin Signaling Biomarkers in Adults With Cardiometabolic Risk.

Compr Physiol · 2026 · PMC13013089 · PMID 41876945

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did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)
However, plasma glucose tAUC 0–150min tended to be lower, albeit it did not reach statistical significance, following exercise ( p = 0.08, d = 0.50), despite no difference in plasma insulin tAUC 0–150min between conditions ( p = 0.99, d = 0.00; Table 1 ). 3.3. nEV Insulin Signaling Biomarkers The acute exercise bout increased pIR‐Tyr1162/Tyr1163 (condition effect; p = 0.05, η 2 = 0.05; Figure 2 ) and pIRS‐1‐Ser636 (condition effect; p = 0.02, η 2 = 0.07; Figure 2 ) compared with the resting condition.

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