Iron toxicity undermines microfracture-induced cartilage regeneration by predisposing a pre-ferroptotic niche.

For Col1a1 and Col2a1, upward trends were observed in the FER-1 group, although these did not reach statistical significance ( Figure 7D ).

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Specifically, the relative abundance of SPs significantly increased in the MF group compared to that in the CON group, while FAs showed an increasing trend ( Figure 3F ).

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