SIRT3 activation protects from nabumetone-induced mitochondrial toxicity in adult human cardiomyocytes.

Consistently, we observed significant reduction in complex II activity, as well as a decreasing trend of complex III activity (Fig. 3 E).

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EP 4 agonist showed a trend towards rescuing maximal respiration and spare respiratory capacity (Fig. 4 H and I).

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Similar to hPCMs, nabumetone showed a trend toward reduced MMP, while the addition of honokiol exhibited an increasing trend (Fig. 6 F).

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