Total FOXO1 protein levels in sWAT showed a trend similar to that of the mRNA levels; the effect of cold exposure on increasing FOXO1 levels in control sWAT was attenuated in AdR2KO sWAT ( Figure 4 E), indicating that ROCK2 is necessary for cold-induced Foxo1 expression.
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Induction of adipocyte thermogenic program by Rho-associated coiled-coil containing kinase 2.
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