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FENDRR-mediated regulation of osteoclast differentiation through the miRNA-129-5p/P2X7R axis.

J Orthop Surg Res · 2026 · PMC13014784 · PMID 41703627

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Subsequent administration of P2X7R inhibitor oxATP to both OE-FENDRR + NC mimic and OE-FENDRR + miRNA-129-5p mimic groups led to a further decrease in the expression of these inflammatory mediators in the OE-FENDRR + miRNA-129-5p mimic group; however, the observed reduction did not reach statistical significance (Fig. 5 D).

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