chemogenetically) and thereby produce a highly significant reduction in food intake, or when almost all PPG neurons are ablated as in this study, which then leads to overeating and slow excessive weight gain.
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Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice.
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The sentences
This revealed significantly elevated GLP-1 content in the hypothalamus (a major PPG neuron projection target) in the obese state, with near-significant increases also observed in brainstem and spinal cord ( Fig 6 C).