Risk of intestinal cancer in Crohn's disease: re-analysis and meta-regression of population-based cohort studies.

J Crohns Colitis · 2026 · PMC13016771 · PMID 41778611

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0530

boldest claim

The sentences

a negative trendP = .05actually significant

We observed a negative trend in the SIR of CRC for the middle year of the observation period (−2.6% per year, P = .05).

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marginally non-significantP = .053so close (0.05 < p ≤ 0.1)

In the PRE subgroup, the pooled effect was lower and marginally non-significant (1.73, 95% CI 0.99-3.02; P = .053), with a wider prediction interval (0.38-7.79).

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an increasing trendno p-value reported

Notably, during the period of observation, there is an increasing trend in the CRC SIR in North America, whereas there is a declining trend in Central–Southern Europe.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.