Identification and assessment of paediatric cefepime-induced neurotoxicity in a retrospective cohort of paediatric intensive care patients.

J Antimicrob Chemother · 2026 · PMC13016889 · PMID 41793739

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

Patients with probable CIN demonstrated a trend towards lower cefepime clearance compared with their none/doubtful counterparts, but this difference did not reach statistical significance (4.1 versus 6.3 L/h/70 kg, P = 0.06).

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did not achieve significanceP = 0.08so close (0.05 < p ≤ 0.1)

Interestingly, contrary to previous studies in adults, the differences in C min did not achieve significance (53.4 versus 14.9 mg/L, P = 0.08).

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