Then and Now: What We Have Learned From the WHI.

J Clin Endocrinol Metab · 2026 · PMC13017459 · PMID 41379766

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did not reach statistical significanceno p-value reported

At trial termination, the results indicated a possible increased risk of ovarian cancer; however, the findings did not reach statistical significance ( 58 ).

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marginally nonsignificantno p-value reported

In the WHI randomized trial involving postmenopausal women with hysterectomy, use of CEE for a median of 5.9 years was associated with a marginally nonsignificant 23% reduction in invasive BC incidence compared with placebo ( 10 ).

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