Efficacy of Praziquantel for Treatment of Plasmodium falciparum Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial.

On day 7 there was yet again a higher proportion of participants with parasite clearance in the PZQ group without previously requiring antimalarial rescue treatment compared with the placebo group; however, this did not reach statistical significance (ITT, 41% [9/22] vs 27% [6/22], respectively; P = .34).

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Analytical models indicated a highly significant hourly reduction of microscopically determined parasitemia in the PZQ arm and a nonsignificant decreasing trend in the placebo group (regression slopes of log 10 -transformed parasitemia: β=−0.006 [ P < .001] and β=−0.0013 [ P = .3], respectively).

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