Barely Significant
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Predictors and long-term impact of sustained complete renal response in lupus nephritis patients over a median 10-year follow-up.

Rheumatology (Oxford) · 2026 · PMC13017678 · PMID 41390925

2
hedged sentences
0.0700
closest p · 1.4× alpha
0.0700
boldest claim

The sentences

a marginal trendP -value = 0.07so close (0.05 < p ≤ 0.1)
In the subgroup analysis of patients with extended follow-up, sCRR duration of minimum 3 years showed a marginal trend (OR: 0.22, P -value = 0.07), while sCRR duration of at least 4 years (adjusted OR: 0.10, P -value = 0.005) was significantly associated with lower risk of severe kidney function decline ( Table 4 ), along with persistent HCQ use (adjusted OR: 0.07, P -value = 0.02).

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Patients who never achieved sCRR for ≥12 consecutive months had slightly lower eGFR (82.5 vs 99 ml/min/1.73 m 2 , P -value = 0.09), higher prevalence of proliferative LN (PLN) (83.3% vs 68.4%, P -value = 0.07) and moderate/severe IF/TA (20.8% vs 8.8%, P -value = 0.08) at baseline compared with sCRR achievers, although these differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.