a marginal trendP -value = 0.07
In the subgroup analysis of patients with extended follow-up, sCRR duration of minimum 3 years showed a marginal trend (OR: 0.22, P -value = 0.07), while sCRR duration of at least 4 years (adjusted OR: 0.10, P -value = 0.005) was significantly associated with lower risk of severe kidney function decline ( Table 4 ), along with persistent HCQ use (adjusted OR: 0.07, P -value = 0.02).