Clinical and molecular data to predict flares in DMARD optimization in rheumatoid arthritis: a randomized, controlled, open-label, non-inferiority trial.

Rheumatology (Oxford) · 2026 · PMC13017882 · PMID 41578952

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = 5 × 10 −7actually significant

The model demonstrated good discriminative performance at 12 months, with a concordance C-index of 0.884, and was highly significant overall χ 2 = 44.18, 8 df; P = 5 × 10 −7 .

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did not reach statistical significanceno p-value reported

Analysis of flare-free survival showed a HR = 1.33 (0.71–2.51) over 12 months of follow-up, which did not reach statistical significance.

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