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Exploratory analysis of prognostic factors and hematologic dynamics in unresectable ESCC treated with concurrent versus interval immune checkpoint inhibitors combined with (chemo)radiotherapy: a multicenter real-world study.

Front Immunol · 2026 · PMC13018115 · PMID 41909696

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a positive trendno p-value reported
Consequently, while our results suggest a positive trend, the survival benefits of ICI maintenance must be interpreted with caution and ultimately require confirmation in prospective randomized controlled trials.

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Patients in the concurrent group had better ECOG performance status, although the difference did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.