Comparison of Anticoagulant Effects of Nafamostat Mesilate and Heparin in Continuous Renal Replacement Therapy for Patients with High Bleeding Risk: A Meta-Analysis Systemic Review.

Kidney Dis (Basel) · 2026 · PMC13019160 · PMID 41909499

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did not reach statistical significanceno p-value reported

The subgroup analysis comparing the nafamostat group to the heparin group showed that nafamostat mesilate (NM) significantly reduced the risk of bleeding compared to LMWH (RR = 0.20, 95% CI: [0.06, 0.71], p = 0.013), while the bleeding risk in the unfractionated heparin group (RR = 0.46, 95% CI: [0.20, 0.74], p = 0.071) showed a downward trend but did not reach statistical significance.

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