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Safety and effectiveness of phenobarbital vs. benzodiazepines for severe alcohol withdrawal in alcohol-associated liver disease in the ICU.

JHEP Rep · 2026 · PMC13019541 · PMID 41861676

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Although differences did not reach statistical significance across all outcomes, phenobarbital performed as well as, and in several domains appeared better than, benzodiazepines in this high-risk population, suggesting it represents a viable alternative for the management of severe alcohol withdrawal in patients with advanced liver disease.

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