Transcranial alternating current stimulation at 10 Hz promotes oligodendrogenesis and reduces g-ratio after cuprizone-induced demyelination.

iScience · 2026 · PMC13020104 · PMID 41907448

Europe PMC DOI

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0.0519

closest p · 1.0× alpha

0.0519

boldest claim

The sentences

borderline significantp = 0.0519so close (0.05 < p ≤ 0.1)

CPZ had a strong effect on the density of OLs that had proliferated during the stimulation period (EdU + OLIG2 + ) (F(1,28) = 34.79, p < 0.0001; see Figure 2 E), and tACS tended to increase the number of these OLs, with a borderline significant stimulation effect (F(1,28) = 4.124, p = 0.0519) and interaction effect between diet and stimulation (F(1,28) = 3.785, p = 0.0618).

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did not reach statistical significanceno p-value reported

Further, tACS 10 Hz tended to increase the density of immature OLs (F(1,28) = 2.923, p = 0.0984) but this did not reach statistical significance.

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