Activation of hypoactive parvalbumin-positive fast-spiking interneurons restores dentate inhibition to reduce electrographic seizures in the mouse intrahippocampal kainate model of temporal lobe epilepsy.

Neurobiol Dis · 2024 · PMC13023382 · PMID 39542222

Europe PMC DOI

hedged sentences

0.1650

closest p · 3.3× alpha

0.1650

boldest claim

The sentences

did not reach statistical significancep = 0.165not close (p > 0.1)

However, the difference in rheobase between the two cohorts did not reach statistical significance ( p = 0.165).

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highly significantno p-value reported

Thus, gaining a deeper understanding of the function of dentate PV+ interneurons in TLE is highly significant.

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