Cutaneous Melanoma Care in Low-Resource Settings: Surgical Disparities in Global Reconstructive Oncology.

40 In a South African cohort, median overall survival with chemotherapy was 5 months, only marginally longer than the 2 months observed in patients receiving no systemic therapy, a difference that did not reach statistical significance ( P = 0.213), highlighting the minimal therapeutic benefit. 40 Although melanoma has historically been considered relatively radioresistant, radiotherapy retains a role in improving locoregional control, particularly in patients with high-risk pathological features such as nodal metastases and in the palliative management of advanced disease.

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