Magnesium Transporter SLC41A1 Links Magnesium Homeostasis to NMDA Receptor-Related Synaptic Dysfunction: A Transdiagnostic Therapeutic Target for Neuropsychiatric Disorders.

Biomedicines · 2026 · PMC13024283 · PMID 41898257

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

borderline significancep ≈ 0.054so close (0.05 < p ≤ 0.1)

ASD exhibited borderline significance with the weighted-median estimator ( p ≈ 0.054), whereas no supporting evidence was observed for anxiety disorder, PTSD, and schizophrenia.

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nominally significantno p-value reported

Colocalization of SLC41A1 Expression and Neuropsychiatric Disorders Colocalization analysis was performed for ten outcomes that satisfied the MR inclusion criteria, comprising four Bonferroni-significant and six nominally significant disorders.

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