Establishing Area-Specific Brain Organoids Through Transcription Factor-Mediated Patterning.

Biology (Basel) · 2026 · PMC13024533 · PMID 41892247

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did not reach statistical significanceno p-value reported

In contrast, DMRTA2-overexpressing hCOs showed significantly increased expression of caudal markers, including NR2F1 , NR2F2 , EMX2 , and FGF3 , compared with control and SP9-overexpressing hCOs; RORB showed an upward trend but did not reach statistical significance.

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