Calcific Aortic Valve Disease: Mechanism and Future Therapeutic Strategies.

Cells · 2026 · PMC13024875 · PMID 41892332

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failed to reach statistical significanceno p-value reported

The trial was designed based on results from the earlier phase 2 study of ataciguat ( NCT02481258 ), which failed to reach statistical significance due to a small sample size and limited follow-up duration [ 71 ].

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