Barely Significant
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<i>SULT</i> and <i>UGT</i> Genetic Variants Modulate Side Effect Profiles in South African Breast Cancer Patients Treated with Tamoxifen.

Genes (Basel) · 2026 · PMC13025226 · PMID 41898786

Europe PMCDOI
2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0910
boldest claim

The sentences

borderline significantp = 0.050actually significant
In multivariate analysis, SULT1E1 rs3736599 remained significantly associated (OR = 2.87; 95% CI = 1.22–6.91; p = 0.016), while SULT1A2*2 showed a borderline significant effect with gynecological symptoms (OR = 2.22; 95% CI = 1.01–5.05; p = 0.050).

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showed a trendp = 0.091so close (0.05 < p ≤ 0.1)
Vasomotor-Associated Side Effects (Hot Flashes) In univariate analysis, individuals homozygous for UGT1A4 rs11888492 showed a trend toward a reduced risk of hot flashes (OR = 0.24; 95% CI = 0.05–1.25; p = 0.091); however, this association did not persist in the multivariate model.

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