Beyond Detection: Comparing State-Based Newborn Screening Methods for Effective Mucopolysaccharidosis I Diagnosis.

Int J Neonatal Screen · 2026 · PMC13026396 · PMID 41892023

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did not reach statistical significanceno p-value reported

Even though this did not reach statistical significance when compared across the MPS I phenotypic spectrum, the states that used second-tier GAGs had a significantly higher yield of severe cases per call-out (3.5%) when compared to the states that did not use second-tier biochemical screening (1.1%), with a p value of <0.001.

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