A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.

Cancer Res Commun · 2026 · PMC13026449 · PMID 41788020

Europe PMC DOI

hedged sentences

0.1700

closest p · 3.4× alpha

0.1700

boldest claim

The sentences

did not reach statistical significanceP = 0.17not close (p > 0.1)

However, this trend did not reach statistical significance ( P = 0.17, log-rank test; Fig. 3B ).

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a numerical trendno p-value reported

Exploration of PSA-PFS showed a numerical trend toward longer median PSA-PFS in patients with at-or-above-median steady-state HCQ levels [6.38 months; 95% CI, 2.76–not applicable (NA)] compared with those with below-median levels (3.81 months; 95% CI, 2.70–NA).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.