Two-Year Implementation, Adherence, and Outcomes of Quadruple Guideline-Directed Medical Therapy in Newly Diagnosed HFrEF: Insights from the Prospective CaRD Registry.

J Clin Med · 2026 · PMC13026455 · PMID 41899053

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did not reach statistical significanceno p-value reported

Figure 3 presents the results of the multivariable regression analysis, demonstrating that adherence to BB (HR 0.25, 95% CI 0.12–0.53, p < 0.001) and SGLT2i (HR 0.31, 95% CI 0.15–0.64, p = 0.002) was significantly associated with a lower risk of mortality or MAE, whereas adherence to ACEi/ARB/ARNI and MRA did not reach statistical significance.

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