BDNF and TNF-α, OCT and VF Parameters in Pituitary Macroadenoma Patients: A 12-Month Prospective Study.

12-month follow-up), a statistically significant difference in MS was observed in the treatment group for the right eye (median MS increased from 24.50 [18.50–27.10] at baseline to 26.00 [22.50–27.70] at 12 months; Δ = +1.50) ( p = 0.0130), while the left eye showed a trend toward significance (median MS increased from 25.40 [15.20–26.70] to 26.10 [17.00–27.30]; Δ = +0.70) ( p = 0.0742).

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In contrast, for TNF-α, no statistically significant difference was observed between baseline and 12-month follow-up in either the treatment group ( p = 0.9521) or the observation group ( p = 0.0656), although the latter showed a trend toward statistical significance.

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