Discordant Perioperative Prophylaxis and Major Morbidity After Pancreatoduodenectomy in Patients Undergoing PTBD: A Culture-Based Analysis.

After adjustment, discordant prophylaxis showed a higher point estimate for major morbidity (adjusted OR: 1.84, 95% CI: 0.63–4.96; p = 0.24), although this did not reach statistical significance.

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In our series, positive preoperative bile culture and high-risk polymicrobial flora indicators were not associated with major complications; in this regard, it appears consistent with studies reporting that bile colonization may be significant in terms of SSI, but cannot determine global major morbidity on its own.

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