<i>miR-374b-5p</i> Modulates Melanoma Progression by Targeting VEGFC and Regulating MAPK Signaling in the Tumor Microenvironment.

The difference between the agomiR-374b-5p and antagomiR-374b-5p groups was highly significant ( Figure 3 C,D, p < 0.001).

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Although not statistically significant, Mitf mRNA levels displayed a decreasing trend in the mimic group relative to the other groups ( Figure 1 E, p > 0.05).

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Compared to the control groups, the miR-374b-5p mimic group showed a significant reduction in Vegfc mRNA expression ( Figure 1 E, p < 0.01), whereas the inhibitor group exhibited a nonsignificant trend toward increased Vegfc expression ( Figure 1 E, p > 0.05).

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While the directional trends in pERK, MITF, and downstream targets were consistent with the proposed regulatory axis, the changes did not reach statistical significance in all cases.

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