Locus- and Gene-Level Insights into the Inverse Association Between Alzheimer's Disease and Cancer.

Int J Mol Sci · 2026 · PMC13026669 · PMID 41898760

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp = 1.17 × 10 −55actually significant

In lung adenocarcinoma tissue, CHRNA5 showed a modest positive association with (AD: Z = 2.36, p = 0.018) but a highly significant negative association with lung cancer (LC: Z = −15.72, p = 1.17 × 10 −55 ).

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nominally significantp < 0.05actually significant

For each AD–cancer pair, we prioritized genes that were nominally significant in both traits ( p < 0.05) and exhibited inverse TWAS Z scores.

also in 3,715 other papers

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