Endocannabinoid Enhancement via MAGL Inhibition in CDKL5 Deficiency: Selective Cellular Benefits and Domain-Specific Functional Effects in Adult <i>Cdkl5</i> KO Mice.

In contrast, the higher dose of JZL184 did not restore microglial soma size, showing only a weak trend in the cortex and no improvement in the hippocampus, and unexpectedly increased microglial density in the cortex ( Figure 4 B,C).

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Six-week JZL184 treatment produced only minimal effects on this abnormality: although a slight reduction in mean velocity was observed, particularly in the 20 mg/kg group ( Figure 1 F), the change did not reach statistical significance, and JZL184-treated Cdkl5 KO mice remained markedly more active than wild-type animals.

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