Barely Significant
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7-Ketocholesterol Links Sterol Homeostasis to Hedgehog Signaling and Stress-Survival Responses in MSCs from Patients with Acute Myeloid Leukemia.

Int J Mol Sci · 2026 · PMC13026915 · PMID 41898701

Europe PMCDOI
1
hedged sentence
0.3662
closest p · 7.3× alpha
0.3662
boldest claim

The sentences

did not reach statistical significancep = 0.3662not close (p > 0.1)
Regarding cytoplasmic ABCD4, a trend toward differences in concentration was observed, but it did not reach statistical significance ( p = 0.3662; Figure 6 L), and nuclear ABCD4 levels were likewise not significantly different between groups ( p = 0.1442; Figure 6 M). 2.5. 7-Ketocholesterol-Induced Modulation of Signaling Pathways in HD-MSCs and AML-MSCs Considering that 7-KC acts both as a cytotoxic oxysterol and as a modulator of signaling pathways involved in lipid homeostasis, stress response, and stem cell behavior, in the next step we evaluated molecular targets related to these processes in HD-MSCs and AML-MSCs.

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