EDIL3/Del-1-Dependent Induction of AMPKβ Phosphorylation Regulates the Progression of Mesenchymal Stem-like Triple-Negative Breast Cancer.

In multivariable Cox regression analysis adjusted for age, tumor size, lymph node status, histologic grade, and Ki-67, high AMPKβ protein expression was significantly associated with poorer DFS (HR, 2.932; 95% CI, 1.009–8.519; p = 0.048), while only a nonsignificant trend toward poorer DDFS was observed (HR, 2.645; 95% CI, 0.765–9.139; p = 0.124) in patients with early TNBC ( Supplementary Table S2 ).

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In the pilot TMA study, high AMPKβ protein expression showed a trend toward poorer DFS in Kaplan–Meier analysis, while multivariate analysis identified high AMPKβ protein expression as an independent factor associated with poorer DFS in patients with early TNBC.

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