Plasma Proteomics Reveals Persistent and Surgery-Responsive Molecular Signatures in Osteoarthritis Patients.

Int J Mol Sci · 2026 · PMC13027247 · PMID 41898721

Europe PMC DOI

hedged sentence

0.6300

closest p · 12.6× alpha

0.6300

boldest claim

The sentences

did not reach statistical significancep = 0.63not close (p > 0.1)

Specifically, CRTAC1 did not reach statistical significance in either comparison (Pre-Op vs. control: p = 0.63, log 2 FC = 0.13; Post-Op vs. control: p = 0.92, log 2 FC = 0.04), while COMP, although showing statistical significance in the Post-Op comparison ( p = 0.01), did not meet the fold-change threshold at either time point (Pre-Op: log 2 FC = −0.30; Post-Op: log 2 FC = −0.64).

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