Tetrodotoxin Oral Film Attenuates Depression in a Chronic Unpredictable Mild Stress Model in Mice.

Mar Drugs · 2026 · PMC13027479 · PMID 41892953

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did not reach statistical significanceno p-value reported

Compared to the model group, treatments with FLU (18 mg/kg) and TTX (10–40 μg/kg) tended to increase the discrimination index, which suggests a potential improvement in recognition memory, though these changes did not reach statistical significance.

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highly significantno p-value reported

For the groups with drug interventions, the fluoxetine (FLU) group showed a highly significant increase compared to the model group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.