Longitudinal Plasma Metabolomics by GC-MS and LC-MS During Total Parenteral Nutrition After Gastrointestinal Surgery.

One-Carbon Metabolism At later postoperative time points, metabolites associated with one-carbon metabolism, including sarcosine and oxalic acid, showed a decreasing trend. Sarcosine is an intermediate in glycine–serine and one-carbon metabolism, generated via S-adenosylmethionine (SAM)-dependent methylation of glycine and convertible back to glycine.

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Results: At 24 h (T1), nominally significant increases were observed in glycine, tryptophan, isoleucine, and methionine, accompanied by decreases in sarcosine and oxalic acid.

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