Comprehensive In Silico Investigation of L-Glutamine Transporters and Metabolism in Glioblastoma.

Although IDH1 demonstrated a highly significant survival association, it was not pursued further due to its well-established and extensively characterized role as a canonical glioma biomarker, largely driven by mutation-dependent mechanisms rather than transcriptional regulation ( Figure 3 D).

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In contrast, MYC ( p = 0.056), SLC1A5 ( p = 0.054), and SLC25A22 ( p = 0.27) did not reach statistical significance, indicating limited prognostic contribution in this cohort ( Figure 3 F,H,K).

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