Advanced Optimization of Clonazepam-Loaded Solid Self-Emulsifying Drug Delivery Systems: Comparison of Weighted Goal Programming and Desirability Function in a Quality by Design Framework.

Pharmaceutics · 2026 · PMC13029302 · PMID 41900794

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The influence of the solid carrier ratio (F2) on mixing efficiency showed a clear trend decrease CV as F2 values were lower, corresponding to a lower proportion of Aerosil in the Lactose/Aerosil binary mixture ( Figure S6a,c–e ).

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