Development and Evaluation of Compact Semi-Synthetic Promoters for Enhanced Antigen Expression in Adenoviral-Vectored Vaccines.

Vaccines (Basel) · 2026 · PMC13030575 · PMID 41893796

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closest p · 1.6× alpha

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showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

ChAdOx1 using lpCMV elicited the most potent cellular responses (mean ≈5000 SFC/10 6 PBMCs), significantly higher than those elicited by cSE4 ( p < 0.005) and showed a trend toward greater magnitude than cSE5 ( p = 0.08).

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