Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons.

Following the 10 min exposure, we observed an increasing trend in the number of evoked action potentials (APs), having amplitudes of around 100 mV ( Figure 5A ).

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In line with the above-mentioned hypothesis, the amplitudes of the sEPSCs increased significantly in two lines (MCtrl = 22.5 ± 6.5; MPsi 96 hrs; day 10=30.7 ± 4.8, Figure 5D ; MCtrl = 15.9 ± 4.5; MPsi 96 hrs; day 10=27.6 ± 10, Figure 5—figure supplement 1B ), and the frequencies showed a trend to increase similar to Figure 5B , reflecting enhanced network activity (MCtrl = 1.0 ± 1.0; MPsi 96 hrs; day 10=1.5 ± 1.0, Figure 5D ; MCtrl = 1.5 ± 1.7; MPsi 96 hrs; day 10=1.0 ± 0.7, Figure 5—figure supplement 1B ).

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