Beyond readthrough: ataluren restores mitochondrial function and reduces oxidative stress in FANCA-mutated cells via mTOR-DRP1 modulation.

1 B) at 2.5 μM, a decrease in AMP levels was observed over time in both nonsense and missense mutant lymphoblasts, whereas higher concentrations (5 and 10 μM) induced a downward trend that did not reach statistical significance relative to untreated controls.

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4 A, ataluren treatment at all three tested concentrations did not significantly alter MDA levels within the first 24 h, although a decreasing trend was observed.

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