Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia.

JAMA Psychiatry · 2026 · PMC13033174 · PMID 41902754

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Importantly, differential expressed gene (DEG) patterns between SCZ and HC in iNs between predicted and the 310 empirical measured DEGs (ΔSCZ-HC) were correlated ( r = 0.45; P value < 2.2e-16, F test) with 75% of nominally significant genes exhibiting concordant direction of effect (eFigure 4F-H in Supplement 1 ; eTable 6 in Supplement 2 ).

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