Hyperbaric Oxygen Therapy in Managing Chronic Pain Syndromes - A Systematic Review.

Yildiz et al reported a mean decrease of 3.31 points on a 11-point scale following 15 sessions of HBOT at 2.4 ATA (p < 0.001), though between-group differences compared to sham control did not reach statistical significance. 49 Two complementary studies by Izquierdo-Alventosa et al using lower pressure protocols (1.45 ATA, 40 sessions) both observed reductions in VAS scores of 2.47 points (p < 0.05 and p < 0.001), with large within-group effect sizes (Cohen’s d = 1.06 and 1.24). 42 , 45 However, these studies did not report formal between-group statistical comparisons.

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