Minimally invasive surfactant administration in extremely preterm infants <28 weeks gestation with spontaneous breathing: a retrospective quality improvement study on reducing invasive ventilation burden.

Front Pediatr · 2026 · PMC13033681 · PMID 41918700

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did not reach statistical significanceno p-value reported

Interrupted time-series analysis demonstrated an immediate reduction in early IMV duration following MISA implementation, whereas changes in secondary outcomes did not reach statistical significance.

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Minimally invasive surfactant administration in extremely preterm infants &lt;28 weeks gestation with spontaneous breathing: a retrospective quality improvement study on reducing invasive ventilation burden.

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Minimally invasive surfactant administration in extremely preterm infants <28 weeks gestation with spontaneous breathing: a retrospective quality improvement study on reducing invasive ventilation burden.