Targeting <i>SPP1</i> <sup>+</sup>TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer.

J Immunother Cancer · 2026 · PMC13034337 · PMID 41881501

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did not reach statistical significanceno p-value reported

Analysis of the large-scale single-cell cohort in this study indicated a trend toward a higher median proportion of SPP1 + TAMs in right-sided CRC compared with left-sided CRC; however, this difference did not reach statistical significance ( figure 5C ).

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Targeting &lt;i&gt;SPP1&lt;/i&gt; &lt;sup&gt;+&lt;/sup&gt;TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer.

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Targeting <i>SPP1</i> <sup>+</sup>TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer.