A cell line-derived, immune-competent neurospheroid model to study neuroinflammation and human brain disorders.

Front Immunol · 2026 · PMC13035522 · PMID 41924272

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did not reach statistical significanceno p-value reported

Consistent with the expected activation profile, the pro-inflammatory genes IL-8, MMP3, GM-CSF, IL-12α, NLRP3 and iNOS, as well as the neurotrophin NGF and chemokines CCL20, CXCL1 and CXCL2 displayed a significant upregulation, with the exception of iNOS, which did not reach statistical significance ( Figure 2B ).

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