Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.

While IFNγ alone had no detectable effect, the combination of IFNγ, GzmB, and perforin resulted in a consistent trend toward enhanced target cell killing compared with any two- or single-molecule combination across four independent experiments, although the differences did not reach statistical significance.

also in 111,027 other papers