Oral supplementation of sodium butyrate prevents lipid metabolism disorders and intestinal injury by modulating immunity, intestinal barrier functions, and gut microbiota in a corticosterone-induced chronic stress model in mice.

Stress Biol · 2026 · PMC13035998 · PMID 41910919

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an increasing trendno p-value reported

did not reach statistical significanceno p-value reported

In contrast, Fusobacteriota (CON: 0; CORT: 0.0064 ± 0.0027; CORT + NaBu: 0)exhibited an increasing trend in CORT-treated mice, though this change did not reach statistical significance.

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a decreasing trendno p-value reported

In the Novelty-Suppressed Feeding Test, CORT-treated mice exhibited significantly prolonged feeding latency ( P < 0.001) and a decreasing trend in food intake compared to CON mice.

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