A novel locus near ITGB8 among APOE -ε4 non-carriers Specific to APOE- ε4 non-carriers, we identified a locus on chromosome 7 (lead SNP: rs73072750; MAF = 0.11) associated with worse executive functioning at baseline, with a nominally significant interaction effect ( β non-carriers = −0.06, p non-carriers = 4.67 × 10 −10 ; β carriers = 0.02, p carriers = 0.16; β interaction = 0.07, p interaction = 8.55 × 10 −6 ).
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