Percutaneous Closure of Patent Foramen Ovale is Associated With Improvement of Migraine.

Rev Cardiovasc Med · 2026 · PMC13036522 · PMID 41923735

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did not reach statistical significanceno p-value reported

All demonstrated numerical reductions in migraine burden by PFO closure, but improvements did not reach statistical significance for primary endpoints, only for certain secondary endpoints.

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highly significantno p-value reported

Re-analysis of aggregated patient data from two trials using the Amplatzer PFO occluder, or redefining primary endpoints, demonstrated highly significant migraine improvement [ 30 ].

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